Your Journey to Optimal Health Starts Here

At Apicella Health, we understand that every individual is unique, which is why The Precision Health Review offers a personalized approach to uncovering the root causes of your health concerns. Led by Dr. Vincent Apicella, this comprehensive program combines advanced metabolic testing with customized strategies to empower you to take control of your well-being.

Low energy production, potential oxidative stress.

CoQ10

µg/mL

May suggest hormonal imbalance or low T.

Testosterone

ng/dL

May reflect growth hormone deficiency.

IGF-1

ng/mL

Strong marker for rheumatoid arthritis.

Anti-CCP3 IgG and IgA

U

High inflammation, possible heart disease risk.

hs-CRP

mg/L

May indicate thyroid hormone conversion issues.

Reverse T3

ng/dL

Genetic cholesterol risk factor for heart disease.

Lp(a)

mg/dL

Elevated cardiovascular and stroke risk.

Homocysteine

µmol/L

Marker of vascular inflammation and plaque risk.

MPO

pmol/L

Possible insulin resistance or early diabetes.

Fasting Insulin

µU/mL

Low levels linked to metabolic syndrome.

Adiponectin

µg/mL

May suggest leptin resistance or obesity risk.

Leptin

ng/mL

100+ Biomarkers

Our expert-curated panel of over 100 biomarkers gives you an unmatched view into your body’s inner workings—from hormones and heart health to nutrition and inflammation. Designed for proactive health seekers, this test empowers you to track changes, uncover risks early, and optimize every aspect of your well-being—all backed by science, not guesswork.

This category measures the condition of your heart and blood vessels. The biomarkers here evaluate how well fats, cholesterol, and inflammation are being managed inside the body. By assessing markers like ApoB, HDL, triglycerides, Lp(a), and oxidized LDL, we can see how efficiently your body is transporting and clearing fats. Other markers, such as hs-CRP, MPO, and platelets, reveal the level of inflammation or clotting activity that may stress your arteries. Together, these tests show how well your cardiovascular system is aging and help us identify the earliest signs of risk long before symptoms appear.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
Cholesterol, total	150–200 mg/dL	201–220 mg/dL	High >220 mg/dL
LDL Calculation	<100 mg/dL	100–129 mg/dL	High ≥130 mg/dL
LDL Direct	>100 mg/dL	100–129 mg/dL	High ≥130 mg/dL
HDL Direct	>60 mg/dL	50–59 mg/dL	Low <50 mg/dL
Triglycerides	<70 mg/dL	71–99 mg/dL	High ≥100 mg/dL
Cholesterol/HDL Ratio	<3.5	3.5-4.9	High>4.9
Apo B	<80 mg/dL	80–99 mg/dL	High ≥100 mg/dL
Apo A-1	≥140 mg/dL	120–139 mg/dL	Low <120 mg/dL
ApoB : Apo A-1 Ratio	<0.49	0.49–0.69	High >0.69
Lipoprotein(a) [Lp(a)]	<30 mg/dL	30–49 mg/dL	High ≥50 mg/dL
Ox-LDL (Oxidized LDL)	<99.1 U/L	100–120 U/L	High >120 U/L
Myeloperoxidase (MPO)	<599 pmol/L	600–2999 pmol/L	High >2999 pmol/L
hs-CRP (High Sensitivity C-Reactive Protein)	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
Homocysteine	≤9 µmol/L	9.1–12 µmol/L	High >12 µmol/L
Omega-3 Index	≥8%	6–7.9%	Low <6%
Platelets	200–300 x10³/µL	150–199 or 301–350 x10³/µL	Low <150 or High >350 x10³/µL

These biomarkers measure how effectively your body converts food into energy. Glucose, insulin, and HOMA-IR tell us how sensitive your cells are to insulin, a key factor in weight control, energy, and diabetes risk. Adiponectin and leptin reveal how your fat cells communicate with your metabolism. RBC count, MCV, and ferritin show how well oxygen and nutrients are being delivered to your cells, while B12 and folate reflect how efficiently you produce cellular energy. This category helps us identify sluggish metabolism, insulin resistance, or nutrient deficiencies that drain your energy and stall progress.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
Glucose	70–90 mg/dL	91–99 mg/dL	High ≥100 mg/dL
Insulin	<8 µIU/mL	8–12 µIU/mL	High >12 µIU/mL
HOMA-IR	<1.5	1.5–2.4	High >2.5
Hemoglobin A1c	<5.5%	5.6–5.8%	High ≥5.9%
Glycated Serum Protein	< 286 umol/L	286-300 umol/L	High >300 umol/L
Adiponectin	>14 µg/mL	10–13 µg/mL	Low <10 µg/mL
Leptin	<10 ng/mL	10–14 ng/mL	High >14 ng/mL
Adiponectin:Leptin Ratio	>1.5	1.0–1.5	Low <1.0
Uric Acid	3.5–5.5 mg/dL	5.6–6.4 mg/dL	High ≥6.5 mg/dL
Ferritin	50–150 ng/mL	151–300 ng/mL	High >300 ng/mL
Red Blood Cell (RBC) Count	4.0–5.5 x10⁶/µL	3.5-3.9 or 5.6–6.1 x10⁶/µL	Low <3.5 or High >6.1 x10⁶/µL
Hemoglobin	13.5–16.5 g/dL	12.5–13.4 g/dL	Low <12.5 g/dL
Hematocrit	40–48%	38–39%	Low <38%
MCV (Mean Corpuscular Volume)	78-92 x 10³/µL	70-77 10³/µL or 92-98 10³/µL	Low <70 or High >98
Vitamin B12	>550 pg/mL (supplemented levels optimal)	350–550 pg/mL	Low <350 pg/mL
Folate	≥8 ng/mL	6–7.9 ng/mL	Low <6 ng/mL

Your hormones act as messengers that control metabolism, mood, strength, and reproduction. This category looks at the entire hormone network including thyroid, adrenal, pituitary, and sex hormones to see where imbalances may begin. Testosterone, DHEA, estradiol, cortisol, and thyroid hormones (TSH, Free T3, Free T4) reveal how well these systems communicate. LH and FSH show pituitary control, while antibodies like Anti-TPO and Anti-TG uncover autoimmune thyroid activity. These markers explain fatigue, mood changes, low libido, or slow metabolism at their root, not just the symptoms.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
LH (Luteinizing Hormone)	3.0–8.0 mIU/L	2.0–2.9 or 8.1–10.0 mIU/L	Low <2.0 mIU/L or High >10.0 mIU/L
FSH (Follicle-Stimulating Hormone)	3.0–8.0 mIU/L	2.0–2.9 or 8.1–10.0 mIU/L	Low <2.0 mIU/L or High >12.0 mIU/L
Testosterone, total	600–900 ng/dL	350–599 ng/dL	Low <350 ng/dL
Free Testosterone	12–25 pg/mL	6–11 pg/mL	Low <6 pg/mL
SHBG (Sex Hormone Binding Globulin)	30–60 nmol/L	20–29 or 61–75 nmol/L	Low <20 or High >75 nmol/L
DHT (Dihydrotestosterone)	20–85 ng/dL	86–100 ng/dL	High >100 ng/dL
Estradiol	20–35 pg/mL	36–45 pg/mL	High >45 pg/mL
Estrone	10–35 pg/mL	36–45 pg/mL	High >45 pg/mL
Prolactin	4–15 ng/mL	16–19 ng/mL	High ≥20 ng/mL
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL
Cortisol (AM)	10–18 µg/dL	7–9 or 19–21 µg/dL	Low <7 or High >21 µg/dL
DHEA-S	250–450 µg/dL	100–249 µg/dL	Low <100 µg/dL
IGF-1	125–250 ng/mL	105–124 or 251–275 ng/mL	Low <105 or High >275 ng/mL
TSH	0.9–2.5 µIU/mL	2.6–3.0 µIU/mL	High >3.0 µIU/mL
Free T4	1.1–1.7 ng/dL	0.9–1.0 ng/dL	Low <0.9 ng/dL
Free T3	3.2–4.4 pg/mL	2.8–3.1 pg/mL	Low <2.8 or High >4.4 pg/mL
Anti-TPO Antibody	<34 IU/mL		High ≥34 IU/mL
Anti-TG Antibody	<115 IU/mL		High ≥115 IU/mL
PSA (males)	<2.5 ng/mL	2.6–3.9 ng/mL	High ≥4.0 ng/mL

Your liver and kidneys handle most of your body’s detox work by breaking down hormones, filtering toxins, and recycling nutrients. The biomarkers in this category (ALT, AST, GGT, bilirubin, and albumin) tell us how efficiently your liver is processing waste and producing proteins. Kidney function markers like BUN, creatinine, eGFR, and electrolytes show how well your filtration system is performing. Nutrients such as B12, folate, iron, and CoQ10 support methylation and antioxidant protection. Understanding these numbers helps us optimize liver and kidney performance, reduce oxidative stress, and prevent buildup of toxic by products.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
ALT (Alanine Aminotransferase)	<35 U/L	35–55 U/L	High >55 U/L
AST (Aspartate Aminotransferase)	<35 U/L	35–45 U/L	High >45 U/L
ALP (Alkaline Phosphatase)	40–129 U/L		Low <40 U/L
GGT (Gamma-Glutamyl Transferase)	<35 U/L	35–60 U/L	High >60 U/L
Bilirubin, total	0.3–1.2 mg/dL		High >1.2
Albumin	4.0–5.0 g/dL		Low <4.0
Total Protein	6.2–8.0 g/dL		Low <6.2
BUN	8–20 mg/dL		High >20 mg/dL
Creatinine	0.80–1.30 mg/dL		High>1.30
BUN/Creatinine Ratio	10–20		High>20
eGFR	≥80 mL/min/1.73 m²	60–79	Low <60
Calcium	9.2–10.2 mg/dL	10.3-10.5	High>10.5
Sodium	136–145 mmol/L	130-135 or 146-149	Low <130 or High >149
Potassium	3.5–5.1 mmol/L		Low <3.5 or High >5.1
Chloride	98–107 mmol/L		Low <98 or High >107
Carbon Dioxide	18–29 mmol/L		Low <18 or High >29
Serum Osmolality	285–315 mOsm/kg		Low <285 or High >315
Iron	75–125 µg/dL	55–74 or 126–150 µg/dL	Low <55 or High >150 µg/dL
UIBC (Unsaturated Iron Binding Capacity)	120–330 µg/dL	100-119 µg/dL or 331–350 µg/dL	High >350 or Low <100 µg/dL
Ferritin	50–150 ng/mL	151–300 ng/mL	High >300 ng/mL
Transferrin Saturation	15-50%		Low<15 and High 50
Homocysteine	≤9 µmol/L	9.1–12 µmol/L	High >12 µmol/L
Vitamin B12	>550 pg/mL (supplemented levels optimal)	350–550 pg/mL	Low <350 pg/mL
Folate	≥8 ng/mL		Low <8 ng/mL
CoQ10	1.0–2.0 µg/mL	0.70–0.99 µg/mL	Low <0.70 µg/mL

The gut is the gateway to the immune system. These biomarkers show whether the immune response is calm and balanced or stuck in a cycle of inflammation. WBC patterns (neutrophils, lymphocytes, monocytes, and others) reflect how active the immune system is, while antibodies like ANA, Anti-CCP, and Anti-Gliadin reveal autoimmune or food-related triggers. Ferritin, Vitamin D, and CRP link gut inflammation to overall systemic stress. Together, they help us uncover silent inflammation, food sensitivities, and immune imbalances that contribute to fatigue, joint pain, and autoimmunity.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
WBC (White Blood Cell Count)	4.5–7.5 x10³/µL	7.6–10.0 or 3.5–4.4	High >10.0 or Low <3.5
Neutrophils	45–65%	66–75% or 40–44%	High >75% or Low <40%
Lymphocytes	25–40%	20–24% or 41–55%	Low <20% or High >55%
Monocytes	4–10%	11–12% or 2–3%	High >12% or Low <2%
Eosinophils	0–3%	4–7%	High >7%
Basophils	0–1%	1.1–1.5%	High >1.5%
ANA (Antinuclear Antibody)	Negative		Positive
ESR (Erythrocyte Sedimentation Rate)	<15 mm/hr	15–20 mm/hr	High >20 mm/hr
RF IgM (Rheumatoid Factor)	<14 IU/mL	14–25 IU/mL	High >25 IU/mL
Anti-CCP3 Antibody	<20 U/mL	20–39 U/mL	High ≥40 U/mL
CRP (C-Reactive Protein)	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
Ferritin	50–150 ng/mL	151–300 ng/mL	High >300 ng/mL
Anti-Gliadin IgG	<0.94 U/mL	0.95-1.05 U/mL	High ≥1.06 U/mL
Anti-DGP IgA (Deamidated Gliadin Peptide)	<0.94 U/mL	0.95-1.05 U/mL	High >1.06 U/mL
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL

This category measures the body’s overall inflammatory tone, the background noise that drives aging and disease. Markers like hs-CRP, MPO, oxidized LDL, and ferritin show how much oxidative stress your body is carrying. Fatty acid ratios (EPA, AA/EPA, Total Omega-6) reveal how your diet influences inflammation at the cellular level. Elevated uric acid or homocysteine signals poor detox or methylation. Balancing these biomarkers reduces the hidden inflammation that fuels heart disease, joint pain, and brain fog.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
hs-CRP (High-Sensitivity C-Reactive Protein)	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
Myeloperoxidase (MPO)	<599 pmol/L	600–2999 pmol/L	High >2999 pmol/L
Oxidized LDL	<99.1 U/L	100–120 U/L	High >120 U/L
WBC (White Blood Cell Count)	4.5–7.5 x10³/µL	7.6–10.0 or 3.5–4.4	High >10.0 or Low <3.5
Uric Acid	3.5–5.5 mg/dL	5.6–6.4 mg/dL	High ≥6.5 mg/dL
Homocysteine	≤9 µmol/L	9.1–12 µmol/L	High >12 µmol/L
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL
Ferritin	50–150 ng/mL	151–300 ng/mL	High >300 ng/mL
Omega-3 Index	≥8%	6–7.9%	Low <6%
EPA (Eicosapentaenoic Acid)	.15–3.0%	0.1-0.14%	Low <0.1%
Arachidonic Acid (AA)	5–18%	19–21%	High >21%
Linoleic Acid (LA)	3-11%	2-3% and 11-12%	Low <2 and High >12
Total Omega-3	3.0-14%		Low <3.0
Total Omega-6	10–32%	33–35%	High >35%
AA/EPA Ratio (Arachidonic Acid to EPA Ratio)	2-10%	10.1-12%	High >12%

Your brain chemistry depends on healthy hormones, nutrients, and inflammation control. Biomarkers like cortisol, DHEA, and thyroid hormones influence mood, motivation, and focus. Nutrients such as B12, folate, and DHA support neurotransmitter production and brain cell repair. Inflammation markers like hs-CRP and homocysteine tell us how stress or diet might be affecting mental clarity. This category helps us find the biochemical reasons behind anxiety, low mood, or cognitive decline and guides us toward restoring balance naturally.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
Cortisol (AM)	10–18 µg/dL	7–9 or 19–21 µg/dL	Low <7 or High >21 µg/dL
DHEA-S	250–450 µg/dL	150–249 µg/dL	Low <150 µg/dL
Free T3	3.2–4.4 pg/mL	2.8–3.1 pg/mL	Low <2.8 pg/mL or High >4.4 pg/mL
Vitamin B12	>550 pg/mL (supplemented levels considered optimal)	350–550 pg/mL	Low <350 pg/mL
Folate	≥8 ng/mL	6–7.9 ng/mL	Low <6 ng/mL
DHA (Docosahexaenoic Acid)	4.0–8.0%	3.0–3.9%	<3.0%
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL
Homocysteine	≤9 µmol/L	9.1–12 µmol/L	High >12 µmol/L
hs-CRP (High-Sensitivity C-Reactive Protein)	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
Omega-3 Index	≥8%	6–7.9%	Low <6%

Sleep is when your body heals, repairs, and resets hormones. This category tracks how your stress and hormone systems influence rest and recovery. Cortisol and DHEA reflect stress rhythm, testosterone and progesterone govern muscle and nerve recovery, and hs-CRP and Vitamin D reveal how inflammation or nutrient status may affect sleep quality. RBC magnesium measures relaxation capacity inside your cells. When these biomarkers are balanced, you wake refreshed and your body can adapt, recover, and grow stronger.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
Cortisol (AM)	10–18 µg/dL	7–9 or 19–21 µg/dL	Low <7 or High >21 µg/dL
DHEA-S	250–450 µg/dL	150–249 µg/dL	Low <150 µg/dL
Testosterone, total	600–900 ng/dL	350–599 ng/dL	Low <350 ng/dL
Free Testosterone	12–25 pg/mL	6–11 pg/mL	Low <6 pg/mL
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL
hs-CRP (High-Sensitivity C-Reactive Protein)	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
RBC Magnesium	3.9-7.2 mg/dL	3.6-3.8 or 7.3-7.7 mg/dL	Low <3.6 or High >7.7 mg/dL

This category combines the most predictive markers of healthspan and biologic age. Fasting insulin, ApoB, Lp(a), and hs-CRP tell us how well your metabolism and blood vessels are aging. Omega-3 Index, Vitamin D, and homocysteine reflect inflammation and DNA repair. Ferritin, uric acid, and GGT show oxidative stress and detox load, while eGFR indicates kidney function, a key indicator of aging speed. By optimizing these biomarkers, we can reduce disease risk, preserve vitality, and extend both lifespan and healthspan.

Biomarker	Optimal Range	Borderline Range	High/Low Thresholds
Insulin	<8 µIU/mL	8–12 µIU/mL	High >12 µIU/mL
Adiponectin:LeptinRatio (A:L)	>1.5	1.0–1.5	Low <1.0
Vitamin D (25-OH)	50–89 ng/mL	30–49 ng/mL	Low <30 ng/mL
Apolipoprotein B (ApoB)	<80 mg/dL	80–99 mg/dL	High ≥100 mg/dL
Lipoprotein(a) [Lp(a)]	<30 mg/dL	30–49 mg/dL	High ≥50 mg/dL
eGFR	eGFR ≥80	eGFR 60–79	Low eGFR <60
hs-CRP	<1.0 mg/L	1.0–3.0 mg/L	High >3.0 mg/L
Omega-3 Index	≥8%	6–7.9%	Low <6%
Homocysteine	≤9 µmol/L	9.1–12 µmol/L	High >12 µmol/L
Ferritin	50–150 ng/mL	151–300 ng/mL	High >300 ng/mL
Uric Acid	3.5–5.5 mg/dL	5.6–6.4 mg/dL	High ≥6.5 mg/dL
GGT (Gamma-Glutamyl Transferase)	<35 U/L	35–60 U/L	High >60 U/L

See Your Health in Motion

Experience how the Precision Health Review platform brings your data to life, from lab results to lifestyle insights, giving you a clear, real-time view of your body’s progress and potential.

The Ultimate Diagnostic Approach

Imagine a future where you have complete clarity about your health. The Precision Health Review turns that vision into reality with:

Comprehensive Health Risk Questionnaire

More than just a medical history, this in-depth questionnaire uncovers the layers of your experiences, environment, and emotions that have shaped your current state of well-being.

Comprehensive Lab Assessment

Evaluating over 100 advanced metabolic biomarkers, this assessment dives deep into your cellular function. It identifies existing disruptions and provides prognostic indicators of potential future problems before symptoms manifest.

Personalized Lab Review Session

One-on-one with Dr. Apicella, this session combines insights from the questionnaire and lab work to deliver a holistic understanding of your health.

Customized Treatment Plan

Dr. Apicella provides tailored recommendations and strategies to guide you on your journey with accurate and thorough information about your current state of wellness.

Proof of Practice:
Dr. A’s Bloodwork Revealed

Dr. Apicella believes in full transparency. That’s why he’s opening up his personal biomarker data — to prove how powerful lifestyle medicine really is.

874ng/dL

Reference

Testosterone

600-800

0.4mg/L

Reference

hsCRP

≤ 9.0

6.0µmol/L

Reference

Homocysteine

≤ 9.0

5.2%

Reference

A1C

≤ 5.6

<7mg/dL

Reference

Lp(a)

≤ 29.0

148ng/mL

Reference

IGF-1

58.0-219.0

1.5µg/mL

Reference

CoQ10

0.4-1.9

15.7µg/mL

Reference

Adiponectin

5-30

0.5ng/mL

Reference

Leptin

0.5-12.5

4.9µU/mL

Reference

Insulin

2-25

PART 1

Health Insights & Biomarker Testing

Are you seeking clarity in your health journey?

Unlock the power of your health data. The first step of The Precision Health Review focuses on cutting-edge biomarker testing, offering a deep dive into your body’s current state. These insights reveal:

Key indicators of your overall health and wellness.
Potential risks for chronic conditions.
Opportunities to optimize your performance and vitality.

Using state-of-the-art tools and methodologies, we deliver a clear and detailed picture of your health’s foundation.

PART 2

Comprehensive Metabolic Assessment & Solutions

Whether you’re seeking answers to unresolved health challenges or aiming to optimize your well-being, Part 2 of The Precision Health Review is your gateway to clarity and actionable solutions. With Dr. Apicella’s expert guidance, we:

Conduct a comprehensive metabolic assessment to identify underlying imbalances.
Develop a personalized strategy tailored to your unique needs and goals.
Address issues that traditional medicine may have overlooked.

Think of this as your "medical crystal ball" – providing insights into where you are now and charting a path to your healthiest future.

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Precision Health Review Programs

All Aspects of The Health Collective Membership

Comprehensive Health Risk Assessment

Advanced Lab Assessments (100+ Biomarkers)

Personalized Lab Review Session with Dr. A

Customized Treatment Plan

Uncover Answers with Expert Precision

The Precision Health Review Membership

$175

Per month, Billed annualy

Precision Health Review Programs

All Aspects of The Health Collective Membership

Comprehensive Health Risk Assessment

Advanced Lab Assessments (100+ Biomarkers)

Personalized Lab Review Session with Dr. A

Customized Treatment Plan

Uncover Answers with Expert Precision

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A comprehensive lab and lifestyle assessment that delivers actionable insights and a tailored roadmap based on your biomarkers.

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100+ Biomarkers

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